Care for low-testosterone symptoms
Testosterone replacement may help selected symptoms when low levels and an appropriate diagnosis are confirmed.
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NirvanixTopical cream
Vitality
TestosteronePackaging may vary. Compounded by a licensed pharmacy, not Nirvanix.
Hormone care built around you
Vitality
Men's Hormones (TRT) – Testosterone Cream
Help bring back sexual desire and enjoyment when testing confirms low hormone levels, with a treatment routine tailored to you.
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Frequently asked questions
Is a compounded cream the same as the gel in the studies?
No. Concentration, ingredients, application, and absorption can differ. The gel studies provide context but do not prove identical results for this cream.
Can testosterone transfer to another person?
Topical testosterone can transfer through skin contact. Follow the pharmacy's application, handwashing, covering, and contact instructions carefully, especially around children and pregnant people.
Will TRT improve my energy?
Some people report improvement, but fatigue has many causes and clinical trials have not shown consistent benefits on every energy measure. The evaluation should address those other causes too.
Can I use TRT while trying to conceive?
Testosterone can suppress sperm production. Tell your clinician about current or future fertility plans before starting; a different approach may be needed.
Does a longer plan mean a higher dose?
No. Plan length and prescribed dose are separate decisions. Your clinician determines the medication and follow-up based on your clinical findings.
Do I need blood tests before or during TRT?
Diagnosis usually combines symptoms with repeated morning testosterone measurements. Your clinician decides which baseline and follow-up tests are needed. Bring existing results with their dates and collection times; do not order a panel solely from the product name.
How do I choose between cream and injections?
Discuss your routine, comfort with injections, skin-contact precautions, previous treatment, and follow-up needs. Each preparation has its own instructions and monitoring; a higher price or longer plan does not make one the right choice for everyone.
How do I fit this into my current routine?
Share your existing skincare, hormone medicines, and any allergies. Your clinician and pharmacist will confirm the application site, amount, timing, and compatibility with other products for your exact preparation.
Safety information & side effects
Testosterone requires ongoing monitoring.
- Treatment can suppress sperm production and raise red blood cell levels and blood pressure.
- Acne, swelling, breast symptoms, and changes in sleep or urinary symptoms should be discussed with your clinician.
- Cardiovascular trial results do not mean treatment has no risk; the choice of formulation and your medical history matter.
- Compounded medications are not FDA-approved. The clinician and pharmacy must determine whether a compounded preparation is appropriate for your individual needs.
This is a summary, not a complete prescribing guide. Read the information supplied with your prescription. For a severe allergic reaction or another medical emergency, call 911.
Sources & prescribing informationCompare other formulations & protocols
Different strengths, delivery methods, and combinations need their own clinical review.
Clinician reviewedPersonalized careOnline convenience
A closer look
Understand your options.
Start with what this treatment is, why it may be considered, and what to discuss with your clinician.
Sexual desire & wellbeing
Discuss changes in libido and daily wellbeing. Testosterone is not a general erectile-dysfunction treatment.
Labs that guide your care
Follow-up checks help your clinician assess response, blood counts, and whether treatment remains appropriate.
How it works
Replace a deficiency. Follow the response.
Testosterone replacement provides testosterone when a clinical evaluation supports treatment for deficiency. Symptoms, repeat morning blood tests, medical history, and fertility plans all matter. More is not automatically better.
Explore the evidenceResearch over time
How testosterone research unfolds over time.
From early monitoring to longer-term outcomes: checkpoints from testosterone-gel studies and labeling.
The 1.62% gel label calls for a blood-level check around day 14, then day 28. This is a monitoring milestone, not a deadline for feeling different.
Testosterone gel 1.62% · Dosing and monitoring label ↗ (opens in a new tab)In a 227-man trial, sexual-function scores improved from baseline by day 30 with testosterone gel or patches. Both groups received testosterone; there was no placebo group.
Wang et al. · Testosterone gel trial, 2000 ↗ (opens in a new tab)The same trial found gains in lean mass and leg strength by day 90. It studied 1% gel at 50–100 mg daily against a testosterone patch, not compounded cream or injections.
Wang et al. · Testosterone gel trial, 2000 ↗ (opens in a new tab)Among men with anemia and low testosterone in TRAVERSE, 41% with six-month measurements had anemia corrected with 1.62% gel, versus 27.5% with placebo. This was a specific clinical subgroup.
TRAVERSE anemia study · JAMA Network Open, 2023 ↗ (opens in a new tab)In the Testosterone Trials, men 65 and older with low levels had modest sexual-function benefits with 1% gel versus placebo over one year. The main vitality measure did not significantly improve.
Testosterone Trials · NEJM, 2016 ↗ (opens in a new tab)
These checkpoints combine different studies and gel labeling, not one person's expected journey. Findings do not establish the same timing or results for compounded cream or cypionate injections. Your clinician sets monitoring and reviews benefits, side effects, and whether to continue.
Personal care starts with context
Is it right for you?
TRT starts with a diagnosis, not a goal testosterone number.
- Symptoms together with consistently low testosterone measurements.
- Fertility goals, sleep apnea, prostate history, and cardiovascular or clotting conditions.
- Your ability to complete recommended blood tests and follow-up.
The evidence behind the conversation
Research & guidance.
Know what was studied, who took part, and how it relates to this option. Study findings are not a prediction of your results.
Testosterone
87%
Reached normal testosterone levels with adjusted-dose gel[1]
Testosterone
41%
Had anemia corrected after six months of testosterone gel[2]
Published study findings, not Nirvanix patient results. The studied formulation, dose, and population may differ from this offering. These figures do not establish the same outcomes for compounded preparations, other routes, or combination treatments. Individual results vary.
Study details & sources
Testosterone
AndroGel 1%, 50–100 mg daily; 129 appropriately titrated men with hypogonadism and sufficient data at day 180. The study used an active patch comparator, not placebo. A laboratory endpoint, not a symptom-success rate or proof of identical outcomes with this compounded preparation.
AndroGel 1% · Clinical studies, section 14.1 (opens in a new tab)Testosterone
Versus 27.5% with placebo among men with available measurements, from 815 participants with anemia and hypogonadism. Daily 1.62% testosterone gel; not a general anemia treatment or proof of equivalent results with this preparation.
TRAVERSE anemia study · JAMA Network Open, 2023 (opens in a new tab)
01AndroGel 1% · Clinical studies, section 14.1
87% of 129 appropriately titrated men with sufficient data had average serum testosterone within the normal range at day 180.
- Treatment studied / guidance scope
- AndroGel 1%, adjusted to 50, 75, or 100 mg testosterone daily.
- Who it applies to
- Men with hypogonadism; 129 evaluable, appropriately titrated gel recipients from an active-comparator trial.
- Timeframe
- 180 days
- Comparison
- A non-scrotal testosterone patch was the active comparator; 87% is the gel-group result, not a placebo comparison.
What this means for this optionA laboratory endpoint does not establish symptom improvement, long-term safety, or the same outcomes with compounded cream or testosterone cypionate.
Read the source (opens in a new tab)02TRAVERSE sexual-function study · JCEM, 2024
Sexual activity and desire improved more with testosterone than placebo; the activity benefit was maintained at 24 months. Erectile function did not significantly improve.
- Treatment studied / guidance scope
- Daily 1.62% testosterone gel, adjusted using testosterone levels and hematocrit.
- Who it applies to
- 1,161 men ages 45–80 with low libido, confirmed hypogonadism, and cardiovascular disease or increased risk.
- Timeframe
- 6, 12, and 24 months
- Comparison
- Placebo gel
What this means for this optionThe studied gel is different from compounded cream and testosterone cypionate. These findings do not predict an individual's response.
Read the source (opens in a new tab)03TRAVERSE anemia study · JAMA Network Open, 2023
At six months, anemia corrected in 41.0% of testosterone-treated participants with available measurements, versus 27.5% with placebo.
- Treatment studied / guidance scope
- Daily 1.62% testosterone gel.
- Who it applies to
- 815 men with anemia within a trial of 5,204 men ages 45–80 with hypogonadism and cardiovascular disease or risk.
- Timeframe
- Six-month result; follow-up continued beyond one year.
- Comparison
- Placebo gel
What this means for this optionThis is a finding in men with anemia and hypogonadism, not a general anemia treatment or evidence for identical results with other formulations.
Read the source (opens in a new tab)04TRAVERSE cardiovascular study · NEJM, 2023
Major cardiovascular events occurred in 7.0% with testosterone and 7.3% with placebo, meeting the trial's noninferiority criterion.
- Treatment studied / guidance scope
- Daily 1.62% testosterone gel.
- Who it applies to
- 5,246 randomized men ages 45–80 with hypogonadism and cardiovascular disease or elevated risk.
- Timeframe
- Mean follow-up of about 33 months
- Comparison
- Placebo gel
What this means for this optionAtrial fibrillation, acute kidney injury, and pulmonary embolism occurred more often with testosterone. The study does not establish lifelong safety or identical risks across formulations.
Read the source (opens in a new tab)How we work
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Nx Protocol
Fertility Focus
Help your body produce more of its own testosterone while keeping fertility in focus, for men with low levels.
The people behind Nirvanix
Your health deserves a thoughtful conversation.
Our founder, Shane Ali, MD, is a board-certified emergency medicine physician. Meet the Nirvanix team and learn about our approach to care.
Meet the teamYour online clinician is assigned according to your treatment and state.
A little more clarity
Your questions, answered.
Comparing costs or getting ready to start? Read our care FAQs.
Have a question about your own care? Sign in to your account.
Is a compounded cream the same as the gel in the studies?
No. Concentration, ingredients, application, and absorption can differ. The gel studies provide context but do not prove identical results for this cream.
Can testosterone transfer to another person?
Topical testosterone can transfer through skin contact. Follow the pharmacy's application, handwashing, covering, and contact instructions carefully, especially around children and pregnant people.
Will TRT improve my energy?
Some people report improvement, but fatigue has many causes and clinical trials have not shown consistent benefits on every energy measure. The evaluation should address those other causes too.
Can I use TRT while trying to conceive?
Testosterone can suppress sperm production. Tell your clinician about current or future fertility plans before starting; a different approach may be needed.
Does a longer plan mean a higher dose?
No. Plan length and prescribed dose are separate decisions. Your clinician determines the medication and follow-up based on your clinical findings.
Do I need blood tests before or during TRT?
Diagnosis usually combines symptoms with repeated morning testosterone measurements. Your clinician decides which baseline and follow-up tests are needed. Bring existing results with their dates and collection times; do not order a panel solely from the product name.
How do I choose between cream and injections?
Discuss your routine, comfort with injections, skin-contact precautions, previous treatment, and follow-up needs. Each preparation has its own instructions and monitoring; a higher price or longer plan does not make one the right choice for everyone.
How do I fit this into my current routine?
Share your existing skincare, hormone medicines, and any allergies. Your clinician and pharmacist will confirm the application site, amount, timing, and compatibility with other products for your exact preparation.
Your goals. Your next chapter.
Let’s make your care personal.
Start with your history and a conversation about what matters to you.
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