Nx Protocol
Accelerate & Thrive
Make hunger easier to manage while bringing weight-loss and everyday energy goals into one plan.
A healthier weight. A plan that fits you.
Explore weight care that brings your health history, everyday habits, and treatment options into one conversation.
Explore your options Hear from our patients ↗
Weight management
A healthier weightAppetite balanceLasting habits
Find your starting point
Weight management,
personalized.
Get to know the options. Your clinician helps determine which, if any, fits your health and goals.
3 products
Nx Protocol
Nx Lean
Feel satisfied with less food and make hunger easier to manage, helping you build eating habits that support your weight-loss goals.
Nx Protocol
Lean Balance
An injection-free option for appetite and weight-management goals, in a small tablet that dissolves in your mouth.
More than a treatment
There’s more to your story than a number.
Your appetite, medications, sleep, and medical history all matter. Start with an individual assessment, then work with a clinician on a plan you can understand and follow.
Understand your starting point
Discuss your weight history, current medications, and what you want to change.
Find an appropriate option
Compare treatment forms and bring questions about benefits, risks, and cost to your clinician.
Make room for follow-up
Track tolerability and progress. Your clinician can reassess the plan as your needs change.
Research over time
From appetite research to lasting weight change.
A look at when researchers measured changes with weekly tirzepatide injections, across separate clinical trials.
In a small phase 1 trial of 114 adults without diabetes, the tirzepatide group ate less at a test meal than the placebo group. Researchers also observed lower hunger and appetite scores.
Tirzepatide appetite trial · Nature Medicine, 2025 ↗ (opens in a new tab)Exploratory follow-up in the same trial found lower food-craving scores than placebo. The trial used 5 mg injections for three weeks, then 10 mg; this is not a low-dose treatment forecast.
Tirzepatide appetite trial · Nature Medicine, 2025 ↗ (opens in a new tab)SURMOUNT-4 participants who completed the initial 36 weeks lost 20.9% of their weight on average. This phase used 10 or 15 mg weekly plus lifestyle support, with no placebo comparison.
SURMOUNT-4 · JAMA, 2024 ↗ (opens in a new tab)At week 72 in SURMOUNT-1, average weight reduction was 15% with 5 mg and 20.9% with 15 mg weekly, versus 3.1% with placebo. All groups received lifestyle support; participants did not have diabetes.
SURMOUNT-1 · NEJM, 2022 ↗ (opens in a new tab)At week 88 in SURMOUNT-4, 89.5% who continued tirzepatide kept at least 80% of their initial weight loss, versus 16.6% switched to placebo after week 36. Ongoing treatment was part of that result.
SURMOUNT-4 · JAMA, 2024 ↗ (opens in a new tab)
Month and year labels are approximate; exact study weeks appear in each milestone. These are findings from separate trials, not promised milestones. Study doses, participants, and designs differ. Results do not establish the same outcomes for unspecified low doses, oral troches, compounded preparations, or NAD+ combinations. Treatment suitability, tolerability, and follow-up require individual review.
A little more understanding
What the research found.
A closer look at the 72-week SURMOUNT-1 tirzepatide trial.
Weight research · 5 mg
15.0%
Average weight reduction with 5 mg weekly tirzepatide injections.[1]
Weight research · 15 mg
20.9%
Average weight reduction with 15 mg weekly tirzepatide injections.[2]
A meaningful milestone
85%
Lost at least 5% of their weight with tirzepatide injections.[3]
SURMOUNT-1 findings at 72 weeks with lifestyle support. Studied injection doses differ from some Nirvanix offerings; results are not established for low-dose regimens, oral troches, compounds, or NAD+ combinations.
Study details & sources
Weight research · 5 mg
5 mg weekly plus lifestyle support, versus 3.1% with placebo. Adults with obesity or overweight, without diabetes; 2,539 participants across the trial.
SURMOUNT-1 · NEJM, 2022 (opens in a new tab)Weight research · 15 mg
15 mg injected weekly after dose escalation, with lifestyle support, over 72 weeks; 3.1% with placebo. This was not a low-dose or oral regimen.
SURMOUNT-1 · NEJM, 2022 (opens in a new tab)A meaningful milestone
5 mg tirzepatide injected weekly for 72 weeks: 85% achieved at least 5% weight reduction, versus 35% with placebo. Both groups received lifestyle support. SURMOUNT-1 enrolled 2,539 adults with obesity or overweight and a weight-related condition, without diabetes. The treatment-regimen result does not establish outcomes for unspecified low doses, oral troches, compounds, or NAD+ combinations.
SURMOUNT-1 · NEJM, 2022 (opens in a new tab)
The details, side by side
Find the option to discuss.
Compare ingredients, forms, and prices before you begin your assessment.
| Treatment | Form / plan | Price & billing | Explore |
|---|---|---|---|
Accelerate & ThriveGLP-1 and NAD - Injection | Injectable care plan | Price pending | View option ↗ |
Nx LeanGLP-1 Weight Loss – Tirzepatide (2.5 mg/week) - 3 Month Supply - Injection | Injection | Price pending | View option ↗ |
Lean BalanceGLP-1 Weight Loss – Tirzepatide (Troche) | Dissolvable oral troche | Price pending | View option ↗ |
Prices and eligibility may vary. Final fees and billing terms are shown before payment. Your clinician determines whether treatment is appropriate.
How we work
Your next chapter
starts with you.
Tell us about yourself
Choose a treatment and complete its assessment when enrollment is available.
Connect with a clinician
Review your options, including any labs or video visit needed for a decision.
Follow your personal plan
If prescribed, begin treatment and stay connected through your patient portal.
Nirvanix Health
Personal care.
Part of your everyday.
The Nirvanix community
Care that feels personal.
A few words from the people who know us best.
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The people behind Nirvanix
A personal approach to care.
Meet our founder and members of the Nirvanix clinical team. Your online clinician is assigned according to your treatment and state.
Founder
Shane Ali, MD
A board-certified emergency medicine physician who founded Nirvanix Health in Austin.
Physician Assistant
Allie
A physician assistant with experience in emergency medicine and a focus on listening to patient concerns.
Registered Nurse
Julia Freudenberger
A registered nurse with experience in emergency medicine and mental health.
Questions about weight management
Start by comparing the ingredient, treatment form, and price, then bring your weight history, current medications, and goals to the assessment. Your clinician determines whether medication fits your health needs and which option is appropriate. Selecting a product is a starting point for that review.
Open a treatment and use the option selector to compare the available formulations and prices on the same page. Accelerate & Thrive includes tirzepatide and NAD+ in its care plan; choosing it does not establish that adding NAD+ improves weight loss. Ask your clinician why each ingredient would be appropriate for you.
No. Route, dose, absorption, and evidence differ. Results from trials of an approved injectable drug do not establish the same outcomes for an oral troche or compounded preparation. Compounded drugs are not FDA-approved. Ask which evidence applies to the exact formulation being considered.
There is no fixed week when everyone responds. The timeline on this page describes study findings, not your dosing schedule or a promised result. Agree with your clinician on how to track appetite, weight, tolerability, and follow-up alongside your eating and activity habits.
Include the exact medicine, dose, last dose date, and any side effects in your assessment. Also mention previous treatments you stopped and why. Your clinician needs that history before considering a change; do not combine plans or carry a dose from one formulation to another on your own.
Contact your prescribing clinician about symptoms or dose changes, and the dispensing pharmacy about the label, syringe, storage, or how to measure your prescribed amount. Confirm anything unclear before the next dose. The website’s study timeline is not an injection guide.
Your next step
Start with what
matters to you.
A little context can help you find a clearer direction.
Find my starting point ↗